SML2410

ABC99

≥98% (HPLC)

• 동의어(들): 7-(4-Chlorobenzyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 2,3-dihydro-4Hbenzo[b][1,4]oxazine-4-carboxylate
• 실험식(Hill 표기법): C₂₂H₂₁ClN₄O₅
• CAS Number: 2331255-53-7
• Molecular Weight: 456.88
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: O=C(ON(C(N1C2CN(CC1)CC3=CC=C(C=C3)Cl)=O)C2=O)N4C5=CC=CC=C5OCC4
• InChI key: OZPZCETZTBBQBO-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

ABC99 is an N-hydroxyhydantoin (NHH) carbamate-based irreversible, potent and selective inhibitor against the serine hydrolase activity of the Wnt-deacylating enzyme NOTUM (IC50 = 13 nM against NOTUM-mediated labeling of fluorophosphonate (FP) probe), an enzyme that reverses the posttranslational O-linked palmitoleate modification of Wnt proteins. ABC99 prevents NOTUM-mediated negative regulation against Wnt3A-dependent cellular signaling (EC50 = 89 nM by HEK293T TOPflash reporter assay) with excellent selectivity over 65 other serine hydrolases, including PPT1.

Inhibition of NOTUM has therapeutic use in treating degenerative diseases including osteopenia and osteoporosis.

Irreversible, potent and selective inhibitor against NOTUM serine hydrolase activity and sustanins Wnt3A-dependent signaling in the presence of NOTUM.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable