SML3693

RA839

≥98% (HPLC)

• 동의어(들): (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid, RA 839
• 실험식(Hill 표기법): C₂₅H₂₈N₂O₄S
• CAS Number: 1832713-02-6
• Molecular Weight: 452.57
• MDL number: MFCD30182350
• UNSPSC 코드: 12352200
• NACRES: NA.21

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: , White to light brown
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: -10 to -25°C

설명

생화학적/생리학적 작용

Active in vivo, highly selective and potent activator of Nrf2

RA839 is an active in vivo, highly selective and potent activator of Nrf2 (transcription factor NF-E2-related factor 2) signaling. RA839 binds noncovalently to the Nrf2-interacting kelch domain of Keap1 thereby inhibiting the interaction between Keap1 and Nrf2. RA839 inhibits the induction of both inducible nitric oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA-839 is a potent antagonist of Rotavirus propagation in vitro that inhibits viral RNA and protein expression.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable