SML3872
AZ0108
≥98% (HPLC)
동의어(들):
(S)-4-((3-(3-(1,1-difluoroethyl)-6-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)phenyl)difluoromethyl)phthalazin-1(2H)-one, 4-[[3-[[(6S)-3-(1,1-Difluoroethyl)-5,6-dihydro-6-methyl-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]phenyl]difluoromethyl]-1(2H)-phthalazinone, AZ 0108
About This Item
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
-10 to -25°C
SMILES string
FC(C1=CC=CC(C(N2[C@@H](C)CN3C(C2)=NN=C3C(F)(F)C)=O)=C1)(F)C(C4=CC=CC=C45)=NNC5=O
1 of 4
이 품목 | 911399 | 911410 | 911429 |
|---|---|---|---|
| form powder or solid | form powder or chunks | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level - |
| mol wt PEG average Mn 2,000, PLGA average Mn 10,000 (by NMR) | mol wt PEG average Mn 2,000 (by NMR), PLGA average Mn 10,000 (by NMR) | mol wt PEG average Mn 5,000 (by NMR), PLGA average Mn 10,000 (by NMR) | mol wt PEG average Mn 5,000 (by NMR), PLGA average Mn 5,000 (by NMR) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| feed ratio lactide:glycolide 50:50 | feed ratio lactide:glycolide 80:20 | feed ratio lactide:glycolide 80:20 | feed ratio lactide:glycolide 80:20 |
| color white to beige | color off-white to faint brown | color white | color white |
생화학적/생리학적 작용
AZ0108 is an inhibitor of Poly (ADP-ribose) polymerase PARP1, 2, and 6 with approximately 100-fold selectivity against PARP3 and TNKS1. It was shown to block centrosome clustering in HeLa cells with an EC50 value of 53 nM and kill a DLBCL lymphoma cancer cell line with a GI50 value of 17 nM. AZ0108 induces replication stress in tumorigenic cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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