SRP3066

IGF-Binding Protein 7 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• 동의어(들): PGI2-stimulating factor, PSF, Prostacyclin-stimulating factor, Tumor-derived adhesion factor (TAF), IBP-7, IGF binding protein related protein-1 (IGFBPrP1), Mac25
• UNSPSC 코드: 51111800
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥98% (HPLC); ≥98% (SDS-PAGE)
• 양식: lyophilized
• 분자량: 26.4 kDa
• 포장: pkg of 25 μg
• 불순물: <0.1 EU/μg endotoxin, tested
• 색상: white to off-white
• UniProt 수납 번호: Q16270
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... IGFBP7(3490)

설명

일반 설명

IGFBP7 (insulin-like growth factor-binding protein 7) is from the IGFBP superfamily and is widely expressed in tissues. It contains 11 cysteines, a heparin-binding site, a Kazal-type trypsin inhibitor domain and a carboxyl-terminal immunoglobulin-like type C repeat. The IGFBP7 gene is mapped to human chromosome 4q12.

생화학적/생리학적 작용

IGFBP7 (insulin-like growth factor-binding protein 7) works as a tumor suppressor as well as an oncogene by controlling cell proliferation, cell attachment, apoptosis and angiogenesis. It is also involved in TGFβ (transforming growth factor β) signal pathway. IGFBP7 also interferes with the insulin pathway and is associated with the development of diabetes as well as cardiovascular diseases.IGFBP7 binds weakly to IGFs (insulin like growth factors) and strongly to insulin. It mainly participates in IGF-independent pathways.

서열

MSSSDTCGPC EPASCPPLPP LGCLLGETRD ACGCCPMCAR GEGEPCGGGG AGRGYCAPGM ECVKSRKRRK GKAGAAAGGP GVSGVCVCKS RYPVCGSDGT TYPSGCQLRA ASQRAESRGE KAITQVSKGT CEQGPSIVTP PKDIWNVTGA QVYLSCEVIG IPTPVLIWNK VKRGHYGVQR TELLPGDRDN LAIQTRGGPE KHEVTGWVLV SPLSKEDAGE YECHASNSQG QASASAKITV VDALHEIPVK KGEGAEL

물리적 형태

Lyophilized from 10 mM Sodium Phosphate, pH 6.8.

재구성

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable