SRP5205

MBP, GST tagged human

recombinant, expressed in E. coli, ≥65% (SDS-PAGE), buffered aqueous glycerol solution

• CAS Number: 1396823-27-0
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥65% (SDS-PAGE)
• 양식: buffered aqueous glycerol solution
• 분자량: ~36 kDa
• NCBI 수납 번호: NM_001025090
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... MBP(4155)

설명

일반 설명

Myelin basic protein (MBP), an important constituent of the myelin sheath of CNS (central nervous system), is an autoimmunogen. It is mapped to human chromosome 18q.

생화학적/생리학적 작용

MBP or Myelin basic protein forms dimers across the cytoplasmic apposition during the formation of myelin. The region of the protein involved in folding, polymerization and substrate specificities is conserved in various species and it may have a specialized role in protein-lipid interactions in the myelin membrane. MBP is an efficient substrate for numerous protein kinases and share similarities with the MARCKS protein in terms of having extended conformations regulated by their environment, N-terminal modifications, a dual nature of interactions with lipids, and binding to actin and Ca²⁺-calmodulin. Myelin basic protein (MBP) is expected to play a vital role in demyelinating diseases such as MS (multiple sclerosis).

물리적 형태

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

제조 메모

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable