T182

Tyrphostin A9

solid

• 동의어(들): Malonoben, [[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile
• 실험식(Hill 표기법): C₁₈H₂₂N₂O
• CAS Number: 10537-47-0
• Molecular Weight: 282.38
• MDL number: MFCD00209853
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24278069
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: yellow
• mp: 139-140 °C
• solubility: ethanol: 20 mg/mL; DMSO: <25 mg/mL; H₂O: insoluble
• SMILES string: CC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C
• InChI: 1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3
• InChI key: MZOPWQKISXCCTP-UHFFFAOYSA-N
• 유전자 정보: human ... EGFR(1956), ORAI1(84876), PDGFRA(5156), PDGFRB(5159) ; mouse ... Eef2k(13631), Prkaca(18747), Prkca(18750), Src(20779)

설명

애플리케이션

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

생화학적/생리학적 작용

Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations.

특징 및 장점

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제조 메모

Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301 + H311
• 예방조치 성명서: P280 - P301 + P310 + P330 - P302 + P352 + P312
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges