T2255

Trifluorothymidine

≥99% (HPLC)

• 동의어(들): α,α,α-Trifluorothymidine, 2′-Deoxy-5-trifluoromethyluridine, Trifluorothymine deoxyriboside, Trifluridine
• 실험식(Hill 표기법): C₁₀H₁₁F₃N₂O₅
• CAS Number: 70-00-8
• Molecular Weight: 296.20
• EC Number: 200-722-8
• MDL number: MFCD00006534
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24900027
• NACRES: NA.51

속성

• 생물학적 소스: synthetic
• Quality Level: 100
• 분석: ≥99% (HPLC)
• 양식: powder
• mp: 190-193 °C (lit.)
• solubility: water: 50 mg/mL, clear, colorless
• 저장 온도: −20°C
• SMILES string: OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(C(=O)NC2=O)C(F)(F)F
• InChI: 1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
• InChI key: VSQQQLOSPVPRAZ-RRKCRQDMSA-N

설명

애플리케이션

Trifluorothymidine has been used as a component of selection medium to screen thymidine kinase (TK) mutants in lymphoma cells, human lymphoblastoid TK6 cells, and L5178Y mouse lymphoma cells.

생화학적/생리학적 작용

Trifluorothymidine is a thymidine analog and is light sensitive. TFT serves as a thymidine kinase substrate to study enzyme specificity and kinetics. Incorporation of phosphorylated TFT into DNA induces damage, making it useful for DNA repair studies. TFT may also be used in the inhibition of thymidylate synthase and in screening mutant thymidine kinase gene.. It elicits antitumor activity in gastrointestinal (GI) cancers and has therapeutic potential to treat herpetic keratitis.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H341,H351,H361d
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 2 - Muta. 2 - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves