T5443

Tyrphostin AG 825

≥92.5%

• 동의어(들): 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide, Tyrphostin C15
• 실험식(Hill 표기법): C₁₉H₁₅N₃O₃S₂
• CAS Number: 149092-50-2
• Molecular Weight: 397.47
• MDL number: MFCD01074971
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329826823
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥92.5%
• 양식: powder
• solubility: DMSO: soluble; methanol: soluble
• 저장 온도: −20°C
• SMILES string: COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O
• InChI: 1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
• InChI key: KXDONFLNGBQLTN-WUXMJOGZSA-N

설명

애플리케이션

Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells¹.

생화학적/생리학적 작용

EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.

Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells².

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

제조 메모

Tyrphostin AG 825 is soluble in DMSO and methanol.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)