T7947

(R)-Tomoxetine hydrochloride

solid

• 동의어(들): (R)-N-Methyl-γ-(2-methyl­phenoxy)benzenepropanamine hydrochloride, Atomoxetine hydrochloride
• 실험식(Hill 표기법): C₁₇H₂₁NO · HCl
• CAS Number: 82248-59-7
• Molecular Weight: 291.82
• MDL number: MFCD06410992
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278760
• NACRES: NA.77

속성

• 양식: solid
• Quality Level: 100
• 주관자: Eli Lilly
• 저장 온도: 2-8°C
• SMILES string: CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl
• InChI: 1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
• InChI key: LUCXVPAZUDVVBT-UNTBIKODSA-N
• 유전자 정보: human ... SLC6A2(6530)

설명

애플리케이션

(R)-Tomoxetine hydrochloride has been used as a noradrenaline reuptake inhibitor:

• to study the role of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in the pathogenesis of Alzheimer′s disease in mice
• to study its effects on set shifting in rats
• to study its effects on rat brain as a result of its long-term use

생화학적/생리학적 작용

(R)-Tomoxetine hydrochloride is an efficient inhibitor of presynaptic norepinephrine transporters. It also positively regulates the release of acetylcholine in the prefrontal cortex (PFC). (R)-Tomoxetine hydrochloride binds to the serotonin (5-HT) transporter. It is involved in blocking the cortical N-methyl-D-aspartate (NMDA) receptors.. (R)-Tomoxetine hydrochloride exhibits therapeutic effects against attention-deficit/hyperactivity disorder (ADHD) and comorbid oppositional defiant disorder (ODD).

Norepinephrine uptake blocker.

특징 및 장점

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)