V4515

VU0238429

solubility: ≥20 mg/mL in DMSO

• 동의어(들): 1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
• 실험식(Hill 표기법): C₁₇H₁₂F₃NO₄
• CAS Number: 1160247-92-6
• Molecular Weight: 351.28
• MDL number: MFCD16618396
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329829052
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: powder
• 색상: orange
• solubility: DMSO: ≥20 mg/mL
• 저장 온도: 2-8°C
• SMILES string: COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1
• InChI: 1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3
• InChI key: CKLGZXFOLMHCMC-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency.

VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. M5 is thought to regulate cerebral blood flow, and activation of M5 may be therapeutic for Alzheimer′s disease. VU0238429 is the first reported M5-selective small molecule of any kind. It is >30-fold more selective for M5 over M1, M2, M3, and M4.

특징 및 장점

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H319,H400
• 예방조치 성명서: P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
• Hazard Classifications: Aquatic Acute 1 - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable