A7410

Amiloride hydrochloride hydrate

≥98% (HPLC), powder, T-type calcium channel blocker

• Synonym(s): N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
• Empirical Formula (Hill Notation): C₆H₈ClN₇O · HCl · xH₂O
• CAS Number: 2016-88-8
• Molecular Weight: 266.09 (anhydrous basis)
• MDL number: MFCD03703482
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277817
• NACRES: NA.77

Properties

• Product Name: Amiloride hydrochloride hydrate, ≥98% (HPLC), powder
• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: powder
• color: yellow
• mp: 285-288 °C (dec.)
• solubility: H₂O: 50 mg/mL, clear, yellow-green
• originator: Perrigo
• storage temp.: room temp
• SMILES string: O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
• InChI: 1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2
• InChI key: WDZJJRLYFQNCQL-UHFFFAOYSA-N
• Gene Information: human ... ABP1(26), ACCN1(40), ACCN2(41), PLAU(5328), SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), TNF(7124) ; mouse ... Abp1(76507), Accn1(11418), Accn2(11419), Plau(18792), Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278), Slc9a1(20544) ; rat ... Abp1(65029), Accn1(25364), Accn2(79123), Plau(25619), Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782)

Description

Application

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.

Biochem/physiol Actions

Selective T-type Ca²⁺ and epithelial sodium channel blocker

Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Caution

Protect from light.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves