A7410
Amiloride hydrochloride hydrate
≥98% (HPLC), powder, T-type calcium channel blocker
Synonym(s):
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
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About This Item
Empirical Formula (Hill Notation):
C6H8ClN7O · HCl · xH2O
CAS Number:
Molecular Weight:
266.09 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
Recommended Products
Product Name
Amiloride hydrochloride hydrate, ≥98% (HPLC), powder
Quality Level
Assay
≥98% (HPLC)
form
powder
color
yellow
mp
285-288 °C (dec.)
solubility
H2O: 50 mg/mL, clear, yellow-green
originator
Perrigo
storage temp.
room temp
SMILES string
O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Related Categories
1 of 4
This Item | B2417 | SML0460 | SML0604 |
|---|---|---|---|
| form powder | form solid | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. room temp | storage temp. 2-8°C | storage temp. room temp | storage temp. room temp |
| solubility H2O: 50 mg/mL, clear, yellow-green | solubility methanol: 10 mg/mL, DMSO: >20 mg/mL | solubility H2O: 5 mg/mL (clear solution) | solubility H2O: 15 mg/mL, clear |
| color yellow | color yellow | color white to beige | color white to beige |
Application
Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.
Biochem/physiol Actions
Selective T-type Ca2+ and epithelial sodium channel blocker
Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Caution
Protect from light.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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