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B175

Sigma-Aldrich

BW 723C86

≥98% (HPLC)

Synonym(s):

α-methyl-5-(2-thienylmethoxy)-1H-Indole-3-ethanamine monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H18N2OS · HCl
CAS Number:
160521-72-2
Molecular Weight:
322.85
MDL number:
MFCD01321066
UNSPSC Code:
12352200
PubChem Substance ID:
24278284
NACRES:
NA.77
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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 1 mg/mL, clear

SMILES string

Cl.CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12

InChI

1S/C16H18N2OS.ClH/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14;/h2-6,8-9,11,18H,7,10,17H2,1H3;1H

InChI key

PYJBJMIBANAOFJ-UHFFFAOYSA-N

Gene Information

human ... HTR2B(3357)

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SML2910

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ASB14780 ≥98% (HPLC)

SML1913

ASB14780

I-BET469 ≥98% (HPLC)

SML2825

I-BET469

IBR2 ≥98% (HPLC)

SML2257

IBR2

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

5-HT2B serotonin receptor agonist.

Caution

Hygroscopic; photosensitive

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Certificates of Analysis (COA)

    Lot/Batch Number
    029K4608V
    029K4608
    057K46172
    057K4617
    056K4611

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    Massimiliano Mirolo et al.
    European cytokine network, 19(3), 119-122 (2008-09-09)
    Bindarit is an indazolic derivative that is devoid of any immunosuppressive effects and has no effect on arachidonic acid metabolism. However, it has been proved to have anti-inflammatory activity in a number of experimental diseases, including pancreatitis, arthritis, and lupus
    C Zoja et al.
    Kidney international, 53(3), 726-734 (1998-03-21)
    As an alternative to classical immunosuppressants in experimental lupus nephritis, we looked at bindarit, 2-methyl-2-[[1-phenylmethyl)-1H-indazol-3-y1]methoxy]propanoic acid, a novel molecule devoid of immunosuppressive effects, which selectively reduces chronic inflammation in rat adjuvant arthritis. Two groups of NZB/W mice (N = 55
    Weiqiang Chen et al.
    Journal of virology, 89(1), 581-593 (2014-10-24)
    The recent global resurgence of arthritogenic alphaviruses, in particular chikungunya virus (CHIKV), highlights an urgent need for the development of therapeutic intervention strategies. While there has been significant progress in defining the pathophysiology of alphaviral disease, relatively little is known

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