H4131

Hemoglobin porcine

lyophilized powder

• Synonym(s): Hb
• CAS Number: 9008-02-0
• MDL number: MFCD00131282
• UNSPSC Code: 12352202
• eCl@ss: 42030116
• NACRES: NA.61

Properties

• biological source: Porcine
• form: lyophilized powder
• solubility: H₂O: soluble 10 mg/mL
• UniProt accession no.: P02067; P02101
• storage temp.: 2-8°C
• Gene Information: pig ... HBB(407066), HBE1(407067)

Description

General description

Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.

Application

Hemoglobin from porcine was used to test the role of the L-arginine/nitric oxide pathway in relaxation of isolated human penile cavernous tissue and circumflex veins. It was also used to study the role of nitric oxide in neurogenic vasodilation of porcine cerebral artery.

Biochem/physiol Actions

Oxygen transporter, NO scavenger

The Fe²⁺/Fe³⁺ balance is a physiological indicator of blood oxygenation. Deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.

Caution

Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves