M1949

S-methyl-5′-thioadenosine phosphorylase human

• EC Number: 2.4.2.28 (BRENDA, IUBMB)
• UNSPSC Code: 12352204
• NACRES: NA.54

Properties

• recombinant: expressed in E. coli
• Quality Level: 200
• Assay: ≥80% (SDS-PAGE)
• form: solution
• relevant disease(s): cancer
• shipped in: dry ice
• storage temp.: −70°C

Description

Application

S-methyl-5′-thioadenosine phosphorylase human (MTAP) is an enzyme used in cancer research that is deficient in many types of cancer. Decreased MTAP expression may be used as a potential indicator of disease progression of gastrointestinal stromal tumors . MTAP may be a used to develop potential therapeutic strategies for hepatocellular carcinoma (HCC) since MTAP inactivation has been linked to HCC development and invasiveness .

Biochem/physiol Actions

MTAP expression is crucial for the catabolism of methylthioadenosine, which is a by-product of polyamine biosynthesis in the methionine salvage pathway. Protein expression is decreased by homozygous deletion and promoter hypermethylation .

Physical properties

N-terminal GST-tagged 57 kDa protein containing amino acids 2-end.

Physical form

Supplied as a solution in 25 mM Tris-HCl, pH 8.0,100 mM NaCl, 0.05% Tween^®-20, 10% glycerol,and 3 mM DTT.

Legal Information

TWEEN is a registered trademark of Croda International PLC

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable