PZ0285

PD168393

≥98% (HPLC)

• Synonym(s): 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide, PD 168393
• Empirical Formula (Hill Notation): C₁₇H₁₃BrN₄O
• CAS Number: 194423-15-9
• Molecular Weight: 369.22
• MDL number: MFCD02179207
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823812
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 25 mg/mL, clear
• storage temp.: room temp
• SMILES string: C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O
• InChI: 1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H,1H2,(H,21,23)(H,19,20,22)
• InChI key: HTUBKQUPEREOGA-UHFFFAOYSA-N

Description

Application

PD168393 has been used in the acute inhibition of ErbB4.

Biochem/physiol Actions

PD168393 is a 6-acrylamido-4-anilinoquinazoline compound. It increases apoptosis in malignant peripheral nerve sheath tumor cells, stimulated by lysosomal dysfunction.

PD168393 is potent, cell-permeable, irreversible and selective inhibitor of EGF receptor (EGFR) tyrosine kinase and ErbB2. PD168393 has an IC₅₀ value of 0.70 nM for EGFR, and is inactive against insulin, PDGFR, FGFR and PKC.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable