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SML2820

Sigma-Aldrich

SR3335

≥98% (HPLC)

Synonym(s):

ML 176, ML-176, ML176, N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)thiophene-2-sulfonamide, N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-2-thiophenesulfonamide, SR 3335, SR-3335

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About This Item

Empirical Formula (Hill Notation):
C13H9F6NO3S2
CAS Number:
Molecular Weight:
405.34
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)C(O)(C(F)(F)F)c1ccc(cc1)N[S](=O)(=O)c2[s]ccc2

InChI

1S/C13H9F6NO3S2/c14-12(15,16)11(21,13(17,18)19)8-3-5-9(6-4-8)20-25(22,23)10-2-1-7-24-10/h1-7,20-21H

InChI key

LZWUNZRMANFRAO-UHFFFAOYSA-N

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This Item
SML0345SML0494SML1088
A 887826 ≥98% (HPLC)

SML0345

A 887826

SRPIN340 ≥98% (HPLC)

SML1088

SRPIN340

assay

98%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

mp

110 °C (dec.) (lit.)

mp

-

mp

-

mp

-

functional group

amide

functional group

-

functional group

-

functional group

-

Biochem/physiol Actions

SR3335 is a selective partial inverse agonist against the retinoic acid receptor-related orphan receptor ROR-alpha (RORα LBD Ki = 220 nM) that selectively inhibits the constitutive transactivation activity of RORα (IC50 = 480 nM), but not RORβ, RORγ or LXRα, by cell-based reporter assays without affinity toward other RORs. SR3335 effectively suppresses HepG2 cellular RORα target genes expression (5 μM) and improves pyruvate tolerance in DIO mice in vivo (15 mg/kg bid. Ip.) by suppressing gluconeogenesis.
Selective retinoic acid receptor-related receptor RORα partial inverse agonist that improves pyruvate tolerance in DIO mice in vivo.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets.
H Yamamoto et al.
Biochemical and biophysical research communications, 95(1), 474-481 (1980-07-16)
Lanthanide complexes with picolinamide.
Condorelli G, et al.
J. Inorg. Nucl. Chem., 36(12), 3763-3766 (1974)
Ángel Manu Martínez et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(48), 11669-11676 (2017-06-22)
A practical picolinamide-directed C-H functionalization/alkyne annulation of benzylamine derivatives enabling access to the previously elusive 1,4-dihydroisoquinoline skeleton was developed using molecular O
Study properties of molecular imprinting polymer using a computational approach.
Wu L, et al.
Analyst, 128(7), 944-949 (2003)
Jason L Atkins et al.
Journal of the American Chemical Society, 134(33), 13546-13549 (2012-08-07)
Tris-arenes based on either isophthalic acid or 2,6-dipicolinic acid have been known for more than a decade to bind anions. Recent studies have also demonstrated their ability to transport various ions through membranes. In this report, we demonstrate two important

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