SML2891

M871 trifluoroacetate

≥95% (HPLC)

• Synonym(s): Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide, TFA salt, M 871, TFA salt, M-871, TFA salt, Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Glu-His-Pro-Pro-Pro-Ala-Leu-Alal-Leu-Ala-NH2, TFA salt, WTLNSAGYLLGPEHPPPALALA-NH2, TFA salt
• Empirical Formula (Hill Notation): C₁₀₈H₁₆₃N₂₇O₂₈ · xC₂HF₃O₂
• Molecular Weight: 2287.61 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: lyophilized powder
• color: white to off-white
• storage temp.: −20°C

Description

Biochem/physiol Actions

M871 is a type 2-selective galanin receptor antagonist (GalR2/GalR1 K_i = 13.1/410 nM by competitive binding against 0.1 nM porcine galanin using membranes from CHO expressing respective human receptors; GalR2/GalR1 K_i = 2.5/1.1 nM in case of rat galanin) that potently blocks 10 nM rat galanin-induced inositol phosphate production in human GalR2-expressing CHO cells (by 100% with 0.1, 1 or 10 nM M871). M871 is widely employed in cultures (0.1 nM-2.5 μM) and in mice and rats in vivo via ip., brain region- or other site-specific injections.

Selective galanin receptor type 2 (GalR2) antagonist with in vitro and in vivo efficacy.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable