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SML3610

Sigma-Aldrich

Gingerenone A

≥95% (HPLC)

Synonym(s):

(4E)​-1,​7-​bis(4-​hydroxy-​3-​methoxyphenyl)​-4-​Hepten-​3-​one, (E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-one

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About This Item

Empirical Formula (Hill Notation):
C21H24O5
CAS Number:
128700-97-0
Molecular Weight:
356.41
MDL number:
MFCD06656136
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

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Brain Extract Polar

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

packaging

pkg of 1 × 1 g (541602P-1g), pkg of 5 × 100 mg (541602P-500mg), pkg of 1 × 100 mg (541602P-100mg)

packaging

pkg of 1 × 50 g (541601G-50g)

packaging

pkg of 2 × 20 mL (541602C-1g), pkg of 1 × 4 mL (541602C-100mg), pkg of 5 × 4 mL (541602C-500mg)

packaging

pkg of 1 × 100 mg (141101P-100mg), pkg of 5 × 100 mg (141101P-500mg)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

form

powder

form

granular

form

chloroform solution

form

powder

manufacturer/tradename

Avanti Research™ - A Croda Brand

manufacturer/tradename

Avanti Research™ - A Croda Brand

manufacturer/tradename

Avanti Research™ - A Croda Brand

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

lipid extracts

lipid type

phosphoglycerides
phospholipids

lipid type

lipid extracts

lipid type

lipid extracts

Biochem/physiol Actions

Gingerenone A is a potent anticancer agent isolated from Ginger (Zingiber officinale) that exhibits minimal toxicity toward normal cells. Gingerenone A potently inhibits JAK2 (Janus Kinase 2) and S6K1 (p70 ribosomal S6 kinase). Gingerenone A significantly suppressed tumor growth in vivo. Also, it exhibits promising senolytic properties. Gingerenone A selectively eliminate senescent cells in WI-38 human fibroblasts rendered senescent by exposure to ionizing radiation.
JAK2 and S6K1inhibitor; anticancer agent isolated from Ginger; it exhibits promising senolytic properties.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Tao Yu et al.
    Cell, 174(6), 1549-1558 (2018-08-14)
    Engineering microorganisms for production of fuels and chemicals often requires major re-programming of metabolism to ensure high flux toward the product of interest. This is challenging, as millions of years of evolution have resulted in establishment of tight regulation of
    Gauri S Joshi et al.
    Journal of bacteriology, 194(6), 1350-1360 (2012-01-17)
    The cbb(I) region of Rhodopseudomonas palustris (Rp. palustris) contains the cbbLS genes encoding form I ribulose-1,5-bisphosphate (RuBP) carboxylase oxygenase (RubisCO) along with a divergently transcribed regulator gene, cbbR. Juxtaposed between cbbR and cbbLS are the cbbRRS genes, encoding an unusual
    Guilherme Vargas Bochi et al.
    Inflammation, 35(6), 1786-1792 (2012-07-11)
    The accumulation of advanced oxidation protein products (AOPP) has been linked to several pathological conditions. Previous studies have identified AOPP as a novel biomarker of oxidative damage to proteins and a novel class of mediator of inflammation. The aim of
    Roberto Christ Vianna Santos et al.
    Inflammation, 35(3), 1198-1203 (2012-02-14)
    It has been previously showed that fructose-1,6-bisphosphate (FBP) has anti-inflammatory and immunomodulatory effects on several experimental inflammation models. However, the effects and mechanism of FBP on Zymosan-induced acute lung injury (ALI) in mice had not been tested. In this study
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    Chemistry, an Asian journal, 8(1), 88-94 (2012-11-30)
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