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Key Documents

X3629

Sigma-Aldrich

X80

≥98% (HPLC)

Synonym(s):

5-(5-{[1-(3-carboxyphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}-2-furyl)-2-chlorobenzoic acid

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About This Item

Empirical Formula (Hill Notation):
C23H15ClN2O6
CAS Number:
Molecular Weight:
450.83
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

orange

solubility

DMSO: >40 mg/mL

storage temp.

2-8°C

SMILES string

CC1=NN(c2cccc(c2)C(O)=O)C(=O)\C1=C/c3ccc(o3)-c4ccc(Cl)c(c4)C(O)=O

InChI

1S/C23H15ClN2O6/c1-12-17(21(27)26(25-12)15-4-2-3-14(9-15)22(28)29)11-16-6-8-20(32-16)13-5-7-19(24)18(10-13)23(30)31/h2-11H,1H3,(H,28,29)(H,30,31)/b17-11-

InChI key

XZRBYOCWWJMJRZ-BOPFTXTBSA-N

Application

X80 has been used as an inhibitor of nucleotide excision repair (NER) pathway to study its effects on 8-hydroxy-2′-deoxyguanosine (8-OHdG) excision in the zygote post-fertilization.

Biochem/physiol Actions

X80 is a XPA protein inhibitor.
X80 is an inhibitor of xeroderma pigmentosum group A protein (XPA protein) required for the removal of all types of DNA lesions repaired by nucleotide excision repair Including both transcription coupled and global genomic nucleotide excision repair.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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