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Z2126

Sigma-Aldrich

ZAP-70 Tyrosine Kinase human

≥90% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells (Histidine tagged), buffered aqueous glycerol solution, ≥150 U/mg

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About This Item

MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32

recombinant

expressed in baculovirus infected insect cells (Histidine tagged)

Quality Level

Assay

≥90% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

≥150 U/mg

mol wt

70 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... ZAP70(7535)

Application

Human ZAP-70 Tyrosine Kinase was used for mapping the phosphorylation sites on LAT (linker for activation of T cells) for investigating the mechanism of activation of signalling proteins in T cells.

Biochem/physiol Actions

ZAP-70 Tyrosine Kinase is a protein belongs to Syk family and is essential for T cell activation. It facilitates the upregulation of Fas ligand in activation-induced T cell apoptosis. Additionally, it also plays a pivotal role in LFA-1-dependent T Cell Migration.
ZAP-70 is protein tyrosine kinase of the Syk family that is localized exclusively to the cytosol of T cells and natural killer cells. It is required for T cell activation. It is activated by Lck-mediated phosphorylation of its tyrosine residues.

Unit Definition

One unit will phosphorylate 1 nmol polyglutamic acid:tyrosine per min at 37 °C at pH 7.0.

Physical form

Solution in 25 mM HEPES, pH 7.5, containing 150 mM NaCl, 0.5 mM DTT, and 50% glycerol.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1


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