193291

2-Chloropyrimidine

95%

• Synonym(s): 2-Chloro-1,3-pyrimidine, Pyrimidin-2-yl chloride
• Empirical Formula (Hill Notation): C₄H₃ClN₂
• CAS Number: 1722-12-9
• Molecular Weight: 114.53
• Beilstein/REAXYS Number: 107171
• EC Number: 217-020-2
• MDL number: MFCD00006060
• UNSPSC Code: 12352100
• PubChem Substance ID: 24851590
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 95%
• form: crystals
• bp: 75-76 °C/10 mmHg (lit.)
• mp: 63-66 °C (lit.)
• functional group: chloro
• SMILES string: Clc1ncccn1
• InChI: 1S/C4H3ClN2/c5-4-6-2-1-3-7-4/h1-3H
• InChI key: UNCQVRBWJWWJBF-UHFFFAOYSA-N

Description

General description

2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.

Application

2-Chloropyrimidine was used in the synthesis of:

• novel bis(2-(pyrimidin-2-yl)ethoxy)alkanes
• 4′-(1,1′-(5-(2-methoxyphenoxy)-[2,2′-bipyrimidine]-4,6-diyl)bis(1H-pyrazol-3,1-diyl)) dianiline fluorescent dye, biosensor for protein assay
• cis- and trans-octahydropyrrolo[2,3]pyridine derivatives
• 2-amino-4-heteroarylpyrimidines

Other Notes

Remainder 2-hydroxypyrimidine

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319
• pcodes: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: 208.4 °F - closed cup
• flash_point_c: 98 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves