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758035

Sigma-Aldrich

Jones reagent

Synonym(s):

Jone′s reagent, Chromium trioxide solution in sulfuric acid, Sulfuric acid-chromium trioxide mixture

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352000
PubChem Substance ID:
NACRES:
NA.22

Pricing and availability is not currently available.

form

liquid

Quality Level

composition

2 M CrO3 in aqueous H2SO4

reaction suitability

core: chromium
reagent type: catalyst
reagent type: oxidant

density

1.298 g/mL at 25 °C

SMILES string

O=[Cr](=O)=O.OS(O)(=O)=O

InChI

1S/Cr.H2O4S.3O/c;1-5(2,3)4;;;/h;(H2,1,2,3,4);;;

InChI key

HNPXHFOTGAXAJY-UHFFFAOYSA-N

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1 of 4

This Item
SAB5701806SAB5701143SAB1404236
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

-

antibody form

-

antibody form

purified immunoglobulin

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

species reactivity

human, rat, mouse

species reactivity

human, mouse, rat

species reactivity

mouse, human, rat

species reactivity

human

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

4D9, monoclonal

General description

  • Jones reagent is a solution of chromium trioxide in aqueous sulfuric acid.
  • Using acetone as a reaction solvent, the reagent is usually used for the oxidation of primary and secondary alcohols to carboxylic acids and ketones, respectively.
  • The oxidation is very rapid and exothermic.
  • The reagent tolerates a variety of functionalities, such as, for example, unsaturated bonds, which are rarely oxidized.

For a comprehensive review of chromium-based reagents, see "Oxidation of Alcohols to Aldehydes and Ketones" by Tojo and Fernández, Springer Berlin, 2006, 1-97.

Application

Jones reagent can be used:
  • In the oxidative cleavage of various alkenes into carboxylic acids and ketones using a catalytic amount of osmium tetroxide.[1]
  • To prepare symmetrical binaphthols by oxidative dehydrodimerization of substituted naphthols.[2]
  • To synthesize acyl-naphthols and substituted isocoumarins from 2-(4-hydroxy-but-1-ynyl)benzaldehydes.[3]

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Met. Corr. 1 - Muta. 1B - Ox. Liq. 1 - Repr. 2 - Resp. Sens. 1 - Skin Corr. 1A - Skin Sens. 1 - STOT RE 1 Inhalation - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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A technique utilizing chemical reagents for direct measurement of temperature at a local area and its engineering applications.
Saka M and Hasegawa T.
Acta Mechanica Sinica, 25(2), 149-160 (2009)

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