79625

N,N-Dimethylphosphoramic dichloride

≥98.0% (AT)

• Synonym(s): DMPADC, Dimethylamidophosphoric dichloride
• Linear Formula: (CH₃)₂NP(O)Cl₂
• CAS Number: 677-43-0
• Molecular Weight: 161.95
• Beilstein/REAXYS Number: 969956
• EC Number: 211-641-2
• MDL number: MFCD00013896
• UNSPSC Code: 12352100
• PubChem Substance ID: 57652812
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: ≥98.0% (AT)
• form: liquid
• refractive index: n20/D 1.464
• bp: 77-79 °C/11 mmHg (lit.)
• density: 1.362 g/mL at 20 °C (lit.)
• functional group: phosphoramide
• storage temp.: 2-8°C
• SMILES string: CN(C)P(Cl)(Cl)=O
• InChI: 1S/C2H6Cl2NOP/c1-5(2)7(3,4)6/h1-2H3
• InChI key: YNHXBEVSSILHPI-UHFFFAOYSA-N

Description

Application

N,N-Dimethylphosphoramic dichloride can be used as a reagent:

• For the activation of carboxylic acids.
• To prepare functionalized β-lactams by reacting with acetic acids and imines.
• To synthesize phosphoramidic esters by reacting with alcohols in the presence of a base catalyst.
• To prepare [1,2,4]triazolo[4,3-c][1,3,5,2]triazaphosphinine-5-oxide derivatives by reacting with N-alkyl/aryl-N′-(4H-1,2,4-triazol-3-yl) amidines in the presence of triethylamine.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter