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928925

Sigma-Aldrich

Poly(ethylene glycol)-block-poly(2-(Dimethylamino)ethyl methacrylate)

quaternized, PEG average Mn 5,000, quaternized PDMAEMA Mn 18,000

Synonym(s):

PEG-PQDMAEMA, Quaternized PEG-PDMAEMA

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1 EA
CA$78.60

About This Item

Linear Formula:
CH3(C2H4O)nC6H7O2N(C9H18O2NCl)mC7H5S2
UNSPSC Code:
51171641
NACRES:
NA.25

CA$78.60

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Quality Level

100

form

powder

mol wt

PEG average Mn 5,000

color

white to pink

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(R)-(−)-2-Pyrrolidinemethanol

(S)-(–)-α,α-Diphenyl-2-pyrrolidine methanol trimethylsilyl ether 95%

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(S)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol 99%

368199

(S)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol

assay

98%

assay

99%

assay

95%

assay

99%

form

solid

form

-

form

-

form

solid

functional group

hydroxyl, phenyl

functional group

hydroxyl

functional group

phenyl

functional group

hydroxyl, phenyl

optical activity

[α]20/D +69°, c = 3 in chloroform

optical activity

[α]20/D −31°, c = 1 in toluene

optical activity

[α]22/D -50°, c = 1 in chloroform

optical activity

[α]20/D −67°, c = 3 in chloroform

mp

77-80 °C (lit.)

mp

-

mp

-

mp

77-80 °C (lit.)

General description

Poly(ethylene glycol)-block-Poly(2-(Dimethylamino)ethyl methacrylate) quaternized (PEG-b-PQDMAEMA) is a biocompatible block polyelectrolyte composed of a neutral PEG block and a cationic quaternized Poly(2-(Dimethylamino)ethyl methacrylate) (PDMAEMA) block. The PQDMAEMA carries quaternary ammonium salt moieties along the polymer chain.

Application

  • Antimicrobial applications
  • Non-viral gene delivery

    PEG-b-PQDMAEMA is a versatile polymer with applications in antimicrobial applications and gene delivery. Due to its high efficacy in antimicrobial systems, it is an ideal candidate for the fabrication of long-lasting, contact-active bactericidal materials. PQDMAEMA is also a promising material for non-viral gene delivery. PEGylation of PQDMAEMA reduces cytotoxicity and increases gene delivery efficiency.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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