582235
Tetanus Toxin, C-Fragment, Clostridium tetani
The C-terminal binding portion of the heavy chain of tetanus toxin.
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
sterile distilled water: soluble
shipped in
ambient
storage temp.
2-8°C
General description
Caution: may contain trace amounts of intact toxin.
The C-terminal binding portion of the chain of tetanus toxin. The intact toxin is known to block neurotransmitter release at inhibitory synapses in cultured spinal cord cells. Shows trans-synaptic retrograde transport in the central nervous system. Caution: may contain trace amounts of intact toxin. Follow the handling procedure described in the information that accompanies the product.
The C-terminal binding portion of the heavy chain of tetanus toxin.
Biochem/physiol Actions
Primary Target
Useful for binding studies
Useful for binding studies
Product does not compete with ATP.
Warning
Toxicity: Highly Toxic (H)
Physical form
Lyophilized from 10 mM sodium phosphate buffer, pH 7.5.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Once an aliquot has been thawed, do not refreeze. Aqueous stock solutions are stable for 7-10 days at 4°C.
Analysis Note
Single major band by SDS-PAGE
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Poulain, B. 1994. Pathol. Biol. 42, 173.
Williamson, L.C., et. al. 1993. Soc. Neurosci. 19, Abstract 770.10.
Evinger, C. and Erichsen, J.T. 1986. Brain Res.380, 383.
Helting, T.B. and Zwisler, O. 1977. J. Biol. Chem.252, 187.
Matsuda, M. and Yoneda, M. 1977. Biochem. Biophys. Res. Commun.77, 268.
Williamson, L.C., et. al. 1993. Soc. Neurosci. 19, Abstract 770.10.
Evinger, C. and Erichsen, J.T. 1986. Brain Res.380, 383.
Helting, T.B. and Zwisler, O. 1977. J. Biol. Chem.252, 187.
Matsuda, M. and Yoneda, M. 1977. Biochem. Biophys. Res. Commun.77, 268.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
Certificates of Analysis (COA)
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