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PHR1289

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Enalapril Maleate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Enalapril maleate salt, (S)-N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro maleate salt

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About This Item

Empirical Formula (Hill Notation):
C20H28N2O5 · C4H4O4
CAS Number:
76095-16-4
Molecular Weight:
492.52
EC Number:
278-375-7
UNSPSC Code:
41116107
NACRES:
NA.24

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grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP 741
traceable to Ph. Eur. E0109000
traceable to USP 1235300

API family

enalapril

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

C[C@@H](C(N1[C@H](C(O)=O)CCC1)=O)N[C@H](CC(OCC)=O)CCC2=CC=CC=C2.O=C(OO)/C=C\C(O)=O

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(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol 98%

382337

(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol

(R)-(−)-2-Pyrrolidinemethanol 99%

281697

(R)-(−)-2-Pyrrolidinemethanol

(S)-(–)-α,α-Diphenyl-2-pyrrolidine methanol trimethylsilyl ether 95%

677183

(S)-(–)-α,α-Diphenyl-2-pyrrolidine methanol trimethylsilyl ether

(S)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol 99%

368199

(S)-(−)-α,α-Diphenyl-2-pyrrolidinemethanol

assay

98%

assay

99%

assay

95%

assay

99%

form

solid

form

-

form

-

form

solid

functional group

hydroxyl, phenyl

functional group

hydroxyl

functional group

phenyl

functional group

hydroxyl, phenyl

optical activity

[α]20/D +69°, c = 3 in chloroform

optical activity

[α]20/D −31°, c = 1 in toluene

optical activity

[α]22/D -50°, c = 1 in chloroform

optical activity

[α]20/D −67°, c = 3 in chloroform

mp

77-80 °C (lit.)

mp

-

mp

-

mp

77-80 °C (lit.)

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Enalapril Maleate is a drug, which is widely used as an antihypertensive and a vasodilator in congestive heart failure. It is a derivative of 2 amino acids such as L-alanine and L-proline.[1]

Application

Enalapril Maleate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations[2][1] using derivative UV spectrophotometry[2] and chromatography techniques.[2][1]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

A long-acting angiotensin-converting enzyme inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3898 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361fd

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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