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Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
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Other Notes
Product not available in all regions or countries. Analyte Specific Reagent in the United States. Analytical and performance characteristics are not established. To request more information on this product, please contact technical services at 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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J R Chen et al.
The British journal of surgery, 95(1), 102-110 (2007-12-08)
Hereditary non-polyposis colorectal cancer (HNPCC) is characterized genetically by germline mutations in DNA mismatch repair (MMR) genes. Immunohistochemistry (IHC) has high sensitivity and specificity for identifying MMR-deficient tumours. This study investigated the clinical presentations and frequency of HNPCC in Taiwan
David Fallik et al.
Cancer research, 63(18), 5738-5744 (2003-10-03)
The aim of our study was to assess the relationship between colorectal tumor responsiveness to irinotecan and microsatellite instability (MSI), a feature of colorectal tumors with DNA mismatch repair defect. Seventy-two patients with metastatic colorectal cancer were included in our
Andrea E de Jong et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(3), 972-980 (2004-02-12)
Immunohistochemistry (IHC) and microsatellite instability (MSI) analysis can be used to identify patients with a possible DNA mismatch repair defect [hereditary nonpolyposis colorectal carcinoma (HNPCC)]. The Bethesda criteria have been proposed to select families for determination of MSI. The aims
Sharlene Gill et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 11(18), 6466-6471 (2005-09-17)
Most colorectal cancers that have high levels of microsatellite instability (MSI-H) show loss of immunohistochemical expression of proteins that participate in the DNA mismatch repair process, most often involving MLH1 and MSH2. Less commonly, a third DNA mismatch repair protein
Articles
Colorectal cancer is a common occurrence among inhabitants of most Western countries, second only to carcinoma of the lung.
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