288R-1
PMS2 (EPR3947) Rabbit Monoclonal Primary Antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
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Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
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Other Notes
Product not available in all regions or countries. Analyte Specific Reagent in the United States. Analytical and performance characteristics are not established. To request more information on this product, please contact technical services at 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Heather Hampel et al.
The New England journal of medicine, 352(18), 1851-1860 (2005-05-06)
Germ-line mutations in the mismatch-repair genes MLH1, MSH2, MSH6, and PMS2 lead to the development of the Lynch syndrome (hereditary nonpolyposis colorectal cancer), conferring a strong susceptibility to cancer. We assessed the frequency of such mutations in patients with colorectal
Adrian Gologan et al.
Clinics in laboratory medicine, 25(1), 179-196 (2005-03-08)
The reference cancers associated with DNA mismatch repair (MMR)deficiency are the adenocarcinomas of patients with hereditary nonpolyposis colorectal cancer, also known as Lynch syndrome. Sporadic gastrointestinal (GI) carcinomas, most commonly colorectal and gastric carcinomas, may also be associated with deficiencies
Yvonne M C Hendriks et al.
Gastroenterology, 130(2), 312-322 (2006-02-14)
The role of the mismatch repair gene PMS2 in hereditary nonpolyposis colorectal carcinoma (HNPCC) is not fully clarified. To date, only 7 different heterozygous truncating PMS2 mutations have been reported in HNPCC-suspected families. Our aim was to further assess the
Kaspar Truninger et al.
Gastroenterology, 128(5), 1160-1171 (2005-05-12)
Germline mutations in the DNA mismatch repair (MMR) genes MSH2, MSH6, or MLH1 predispose to colorectal cancer (CRC) with an autosomal dominant inheritance pattern. The protein encoded by PMS2 is also essential for MMR; however, alterations in this gene have
Janindra Warusavitarne et al.
International journal of colorectal disease, 22(7), 739-748 (2006-11-17)
High-frequency microsatellite instability (MSI-H) is an alternate pathway of colorectal carcinogenesis, which accounts for 15% of all sporadic colorectal cancers. These tumours arise from mutations in the DNA mismatch repair system and thus have different responses to chemotherapeutic agents compared
Articles
Colorectal cancer is a common occurrence among inhabitants of most Western countries, second only to carcinoma of the lung.
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