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A1737

Sigma-Aldrich

A922500

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About This Item

Empirical Formula (Hill Notation):
C26H24N2O4
CAS Number:
959122-11-3
Molecular Weight:
428.48
MDL number:
MFCD12828780
UNSPSC Code:
12352204
NACRES:
NA.77
Pricing and availability is not currently available.

biological source

synthetic (organic)

Quality Level

100

assay

>95% (HPLC)

form

powder

mol wt

Mw 428.5

solubility

DMSO: 10 mg/mL, clear, colorless to greenish-yellow

storage temp.

−20°C

SMILES string

N(c2ccc(cc2)c3ccc(cc3)C(=O)[C@H]4[C@@H](CCC4)C(=O)O)C(=O)Nc1ccccc1

InChI

1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1

InChI key

BOZRFEQDOFSZBV-DHIUTWEWSA-N

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This Item
P3252D5782E9386
A922500

A1737

A922500

6-Phenyl-2-thiouracil ≥95%

P3252

6-Phenyl-2-thiouracil

2′,3′-Dideoxycytidine ≥98% (HPLC)

D5782

2′,3′-Dideoxycytidine

5-Ethyl-2′-deoxyuridine

E9386

5-Ethyl-2′-deoxyuridine

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

assay

>95% (HPLC)

assay

≥95%

assay

≥98% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

solubility

DMSO: 10 mg/mL, clear, colorless to greenish-yellow

solubility

DMF: 20 mg/mL, clear to slightly hazy, colorless to light yellow

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL, clear, colorless to yellow

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

storage temp.

−20°C

Application

A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231),[1] digitonin-permeabilized human cancer cells,[2] human myotubes[3] and macrophages.[4]

Biochem/physiol Actions

Diacylglycerol acyltransferase (DGAT-1) inhibitor; IC50 7 to 24 nM
The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease. [5]

Physical form

A922500 is supplied as a crystalline solid.

Preparation Note

A stock solution may be made by dissolving the A922500 in the solvent of choice. A922500 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCN9675
    MKCM9085
    MKCM8174
    MKCK5478
    SLBB3548V

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