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A6987

Sigma-Aldrich

Ceftazidime hydrate

Synonym(s):

1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinum

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About This Item

Empirical Formula (Hill Notation):
C22H22N6O7S2 · xH2O
CAS Number:
120618-65-7
Molecular Weight:
546.58 (anhydrous basis)
MDL number:
MFCD00153936
UNSPSC Code:
51284108
PubChem Substance ID:
329770910
NACRES:
NA.85
Pricing and availability is not currently available.

description

does not contain sodium carbonate

Quality Level

200

assay

95.0-102.0% anhydrous basis

form

powder or crystals

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].CC(C)(O\N=C(/C(=O)N[C@H]1[C@H]2SCC(C[n+]3ccccc3)=C(N2C1=O)C([O-])=O)c4csc(N)n4)C(O)=O

InChI

1S/C22H22N6O7S2.5H2O/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;;;;;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);5*1H2/b26-13-;;;;;/t14-,18-;;;;;/m1...../s1

InChI key

NMVPEQXCMGEDNH-TZVUEUGBSA-N

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1 of 4

This Item
C3809SML0056SML0037
Ceftazidime hydrate

A6987

Ceftazidime hydrate

Ceftazidime hydrate 90.0-105.0%, contains ~10% sodium carbonate as stabilizer

C3809

Ceftazidime hydrate

Cefotiam dihydrochloride hydrate ≥98% (HPLC)

SML0056

Cefotiam dihydrochloride hydrate

Ceftibuten hydrate ≥98% (HPLC)

SML0037

Ceftibuten hydrate

mode of action

cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

assay

95.0-102.0% anhydrous basis

assay

90.0-105.0%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder or crystals

form

powder or crystals

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Broad spectrum antibiotic; third generation cephalosporin

Application

Ceftazidime hydrate is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP3 on bacterial cell wall mucopeptide synthesis. It is also used in bacterial susceptibility studies and to select mutant colonies of interest.
Used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP3 on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Cephalosporins, such as ceftazidime , disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    049M4870V
    049M4871V
    048M4823V
    048M4822V
    067M4806V

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    The Journal of antimicrobial chemotherapy, 70(5), 1434-1442 (2015-02-26)
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    David M P De Oliveira et al.
    Science translational medicine, 12(570) (2020-11-20)
    The emergence of polymyxin resistance in carbapenem-resistant and extended-spectrum β-lactamase (ESBL)-producing bacteria is a critical threat to human health, and alternative treatment strategies are urgently required. We investigated the ability of the hydroxyquinoline analog ionophore PBT2 to restore antibiotic sensitivity
    Borys Snopok et al.
    The Analyst, 140(9), 3225-3232 (2015-03-13)
    An ultra-sensitive gas phase biosensor/tracer/bio-sniffer is an emerging technology platform designed to provide real-time information on air-borne analytes, or those in liquids, through classical headspace analysis. The desired bio-sniffer measures gaseous 17α- ethinylestradiol (ETED) as frequency changes on a quartz
    Ruud R G Bueters et al.
    Pediatric research, 76(6), 508-514 (2014-08-29)
    Many premature born neonates receive antibiotic drugs to treat infections, which are applied during active nephrogenesis. We studied the impact of clinical concentrations of gentamicin and alternatives, ceftazidime and meropenem, on ureteric branching. Mice metanephroi were dissected at embryonic day
    Yung-Heng Hsu et al.
    International journal of nanomedicine, 9, 4347-4355 (2014-09-24)
    We developed biodegradable drug-eluting nanofiber-enveloped implants that provided sustained release of vancomycin and ceftazidime. To prepare the biodegradable nanofibrous membranes, poly(D,L)-lactide-co-glycolide and the antibiotics were first dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol. They were electrospun into biodegradable drug-eluting membranes, which were then enveloped

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