C3809

Ceftazidime hydrate

90.0-105.0%, contains ~10% sodium carbonate as stabilizer

• Synonym(s): 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinum
• Empirical Formula (Hill Notation): C₂₂H₂₂N₆O₇S₂ · xH₂O
• CAS Number: 120618-65-7
• Molecular Weight: 546.58 (anhydrous basis)
• MDL number: MFCD00153936
• UNSPSC Code: 51284108
• PubChem Substance ID: 24892644
• NACRES: NA.85

Properties

• Quality Level: 200
• assay: 90.0-105.0%
• form: powder or crystals
• contains: ~10% sodium carbonate as stabilizer
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria
• mode of action: cell wall synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].CC(C)(O\N=C(/C(=O)N[C@H]1[C@H]2SCC(C[n+]3ccccc3)=C(N2C1=O)C([O-])=O)c4csc(N)n4)C(O)=O
• InChI: 1S/C22H22N6O7S2.5H2O/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;;;;;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);5*1H2/b26-13-;;;;;/t14-,18-;;;;;/m1...../s1
• InChI key: NMVPEQXCMGEDNH-TZVUEUGBSA-N

Description

General description

Broad spectrum antibiotic; third generation cephalosporin

Chemical structure: ß-lactam

Application

Ceftazidime hydrate is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP3 on bacterial cell wall mucopeptide synthesis. It is also used in bacterial susceptibility studies and to select mutant colonies of interest.

Used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP3 on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Cephalosporins, such as ceftazidime , disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H317,H319,H334
• pcodes: P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves