C2917

Corticotropin Releasing Factor Antagonist

≥97% (HPLC)

• Synonym(s): α-Helical CRF (9-41), α-Helical corticotropin releasing factor fragment (9-41)
• Empirical Formula (Hill Notation): C₁₆₆H₂₇₄N₄₆O₅₃S₂
• CAS Number: 99658-03-4
• Molecular Weight: 3826.36
• MDL number: MFCD00081543
• UNSPSC Code: 51111800
• NACRES: NA.32

Properties

• Quality Level: 200
• assay: ≥97% (HPLC)
• form: powder
• storage temp.: −20°C
• Gene Information: human ... CRH(1392) ; mouse ... CRH(12918) ; rat ... CRH(81648)

Description

Amino Acid Sequence

Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2

Biochem/physiol Actions

Exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors.

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)