F3004

Fetuin from fetal bovine serum

lyophilized powder

• Synonym(s): Fetuin from fetal calf serum
• CAS Number: 9014-81-7
• EC Number: 232-762-7
• MDL number: MFCD00131055
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• biological source: bovine serum (fetal)
• form: lyophilized powder
• technique(s): HPLC: suitable; MALDI-MS: suitable
• impurities: ~0.2% free N-acetylneuraminic acid
• UniProt accession no.: Q58D62
• storage temp.: 2-8°C
• Gene Information: bovine ... FETUB(504615)

Description

General description

Fetuin is an abundant glycosylated protein from fetal bovine serum and functions as a transport and storage protein. It is also called the α2-Heremans-Schmid glycoprotein (AHSG) and corresponds to a molecular weight of 64 kDa. It belongs to the statin family and is synthesized principally in the liver and partially in the kidneys, placenta and the tongue.

Application

Fetuin from fetal bovine serum has been used:

• as a standard glycoprotein in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) and high-performance liquid chromatography-fluorescence detection analysis (HPLC-FLD)
• as a ligand in carbohydrate binding assay of pertussis toxin vaccine
• in the synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) for drug carrier studies

Biochem/physiol Actions

In humans, polymorphism in the fetuin gene is implicated in type 2 diabetes mellitus and modulates adipocyte functionality. Elevated level of fetuin is observed in obesity and nonalcoholic fatty liver diseases (NAFLD). Fetuin is a potential marker in clinical diagnosis of metabolic disorders.

Preparation Note

Further processing of F2379 by gel filtration.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)