I0779

Interleukin-2 Soluble Receptor α human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

• Synonym(s): CD25, IL-2 sRα, Tac antigen
• MDL number: MFCD01323736
• UNSPSC Code: 51111800
• NACRES: NA.32

Properties

• biological source: human
• Quality Level: 200
• recombinant: expressed in NSO cells
• assay: >97% (SDS-PAGE)
• form: lyophilized powder
• potency: 0.5-1.0 mg per mL ED₅₀
• mol wt: 36 kDa by SDS-PAGE
• packaging: pkg of 5 μg
• impurities: endotoxin, tested
• UniProt accession no.: P01589
• storage temp.: −20°C
• Gene Information: human ... IL2RA(3559)

Description

Biochem/physiol Actions

Interleukin-2 (IL-2), a cytokine, enhances Th (T helper) cell differentiation and effector responses. In addition, it helps in immune tolerance. IL-2 binds to the high affinity receptor, formed of IL2RA (interleukin 2 receptor subunit α), IL2RB (interleukin 2 receptor subunit β) and γ-chain. Polymorphism in IL2RA is associated with multiple sclerosis. Null mutation in IL2RA results in immune dysregulation.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.25 mg bovine serum albumin.

Analysis Note

The bioactivity is measured by its ability to inhibit the IL-2-dependent proliferation of a human megakaryocytic leukemic cell line, M07e.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable