M6684

Anti-Matrix Metalloproteinase-24, Hinge Region antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(s): Anti-MMP-24, Anti-MT5-MMP
• MDL number: MFCD03097031
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous glycerol solution
• mol wt: antigen 65 kDa
• species reactivity: human, mouse
• concentration: ~1 mg/mL
• technique(s): flow cytometry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; western blot: 1:2,000
• UniProt accession no.: Q9Y5R2
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MMP24(10893) ; mouse ... Mmp24(17391)

Description

General description

Matrix metalloproteinase-24 (MMP-24) is expressed majorly in the nervous system and also in the lungs, kidneys and liver. It is a 64kDa protein whose gene is localized on human chromosome 20.

Specificity

Reacts with reduced and native MMP-24. Recognizes the pro-form of MMP-24 as well as activation/breakdown products.

Immunogen

synthetic peptide corresponding to the hinge region of mouse matrix metalloproteinase-24 (membrane-type matrix metalloproteinase-5).

Biochem/physiol Actions

Matrix metalloproteinase-24 (MMP-24) is involved in the conversion of pro-matrix metalloproteinase-2 to its functional active form. It may be important for brain development and studies have shown that it is overexpressed in gastric cancer.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable