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O7139

Sigma-Aldrich

Monoclonal Anti-Oligodendrocyte Marker O4 antibody produced in mouse

clone O4, purified immunoglobulin, lyophilized powder

Synonym(s):

Oligodendrocyte Marker O4 Antibody

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About This Item

MDL number:
MFCD07785411
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

O4, monoclonal

form

lyophilized powder

species reactivity

mouse, rat, chicken, human

technique(s)

flow cytometry: 0.25 μg/106 cells (rate differentiated cortical stem cells)
immunocytochemistry: 1-10 μg/mL

isotype

IgM

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biological source

rat plasma

biological source

human plasma

biological source

human

biological source

human plasma

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

form

lyophilized powder

form

lyophilized powder

form

lyophilized

form

lyophilized powder

mol wt

75 kDa

mol wt

A subunit 75 kDa, B subunit 65 kDa

mol wt

52.2 kDa (calculated)

mol wt

45 kDa

packaging

pkg of 50 μg

packaging

pkg of 50 μg

packaging

pkg of 250 μg

packaging

pkg of 0.5 mg

General description

Monoclonal anti-oligodendrocyte marker O4 was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with white matter of the corpus callosum from bovine brain. Oligodendrocytes are myelinating cells in the central nervous system (CNS) that form the myelin sheath of axons to support rapid nerve conduction.

Immunogen

white matter of corpus callosum from bovine brain.

Application

Monoclonal anti-oligodendrocyte marker O4 antibody produced in mouse has been used in immunocytochemistry and immunofluorescence.

Biochem/physiol Actions

Oligodendrocyte marker O4 functions as a development marker of oligodendrocytes. The monoclonal anti-oligodendrocyte marker O4 antibody has been used to describe a biologically distinct stage of the oligodendroglial lineage in-vitro.†

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    SLCL3047
    SLCK5352
    SLCC1597
    SLBX6296
    SLBV7695

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    SDF-1a Secreted by Human CD133-Derived Multipotent Stromal Cells Promotes Neural Progenitor Cell Survival Through CXCR7
    Benjamin Bakondi
    Stem Cells and Development (2011)
    An efficient and economical culture approach for the enrichment of purified oligodendrocyte progenitor cells.
    Niu J, et al.
    Journal of Neuroscience Methods, 209, 241-249 (2012)
    M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPAR? signaling pathway
    Jichao Yuan
    Oncotarget (2017)
    Oligodendrocytes: biology and pathology
    Bradl M, et al.
    Acta Neuropathologica, 119, 37-53 (2010)
    Neuroglial Cells in Long-Term Primary Cultures from the Gilthead Seabream (Sparus Aurata L.): New Functional In Vitro Model from Bony Fish Brain
    Centoducati G, et al.
    Italian Journal of Animal Science, 12 (2013)
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