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MilliporeSigma

SAB4200545

Sigma-Aldrich

Anti-Parvalbumin antibody, Mouse monoclonal

clone PARV-19, purified from hybridoma cell culture

Synonym(s):

Monoclonal Anti-ALPHA-PARVALBUMIN, Monoclonal Anti-PALB1, Monoclonal Anti-PV, Monoclonal Anti-PVALB (includes EG:19293), Monoclonal Anti-Parv, Monoclonal Anti-Pva

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.44

Pricing and availability is not currently available.

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

PARV-19, monoclonal

form

buffered aqueous solution

mol wt

antigen 12 kDa

species reactivity

rat, human

concentration

~1.0 mg/mL

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P3088SAB4200503SAB4200473
species reactivity

rat, human

species reactivity

fish, frog, rabbit, canine, feline, bovine, pig, human, goat, rat

species reactivity

human, rat, mouse

species reactivity

human, mouse

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... PVALB(5816)
rat ... PVALB(25269)

Gene Information

human ... PVALB(5816)
rat ... Pvalb(25269)

Gene Information

human ... PSPC1(55269)
mouse ... Pspc1(66645)
rat ... Pspc1(305910)

Gene Information

human ... EPCAM(4072)
mouse ... Epcam(17075)

clone

PARV-19, monoclonal

clone

PARV-19, monoclonal

clone

1L4, monoclonal

clone

4A7, monoclonal

antibody form

purified from hybridoma cell culture

antibody form

ascites fluid

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

General description

Monoclonal Anti-Parvalbumin (mouse IgG1 isotype) is derived from the hybridoma PARV-19 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified frog muscle parvalbumin. Parvalbumin (PV) is a member of the family of Ca2+-binding molecules. It carries three helix-loop-helix EF-hand Ca2+ binding motifs, with the two C-terminal motifs.

Specificity

Monoclonal Anti-Parvalbumin recognizes parvalbumin in a Ca2+ -ion dependent manner

Immunogen

purified frog muscle parvalbumin. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).

Application

Anti-Parvalbumin antibody, Mouse monoclonal has been used in:
  • immunohistochemistry[1]
  • immunofluorescence staining
  • immunolabeling[2]
  • to label brain slices for perineuronal net staining[3]
  • enzyme-linked immunosorbent assay (ELISA)
  • immunocytochemistry

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

Ca2+ participates in cell motility, release of neurotransmitters, membrane permeability, excitation−contraction of muscles, cell secretory procedures, and transmission of nerve impulses. Intracellular Ca2+ exchangers are essential to modulate these processes efficiently. Parvalbumin (PV), a calcium-binding protein, can regulate the intracellular calcium dynamics in neurons. Hence it may have an impact on facilitation and depression at synapses. Interestingly, PV deficiency alters neuronal activity, a key mechanism leading to epileptic seizures or Parkinson.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Céline Loriol et al.
Nature communications, 5, 5113-5113 (2014-10-15)
Sumoylation plays important roles in the modulation of protein function, neurotransmission and plasticity, but the mechanisms regulating this post-translational system in neurons remain largely unknown. Here we demonstrate that the synaptic diffusion of Ubc9, the sole conjugating enzyme of the

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