SBR00079

Delamanid

≥98% (HPLC), powder

• Synonym(s): OPC-67683
• Empirical Formula (Hill Notation): C₂₅H₂₅F₃N₄O₆
• CAS Number: 681492-22-8
• Molecular Weight: 534.48
• UNSPSC Code: 51101500

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: dry media
• color: white to off-white
• antibiotic activity spectrum: mycobacteria
• mode of action: cell wall synthesis | inhibits
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: C[C@@]1(CN2C=C(N=C2O1)[N+](=O)[O-])COC3=CC=C(C=C3)N4CCC(CC4)OC5=CC=C(C=C5)OC(F)(F)F
• InChI: InChI=1S/C25H25F3N4O6/c1-24(15-31-14-22(32(33)34)29-23(31)38-24)16-35-18-4-2-17(3-5-18)30-12-10-20(11-13-30)36-19-6-8-21(9-7-19)37-25(26,27)28/h2-9,14,20H,10-13,15-16H2,1H3/t24-/m1/s1
• InChI key: XDAOLTSRNUSPPH-XMMPIXPASA-N

Description

General description

Delamanid is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds that inhibits mycolic acid synthesis of bacterial cell wall. A limitation of dasabuvir is the lower potential for cross-genotypic activity as the binding sites are poorly preserved across HCV genotypes.

Biochem/physiol Actions

Delamanid is an antimycobacterial agent that inhibits mycolic acid synthesis, an essential component of the cell wall of Mycobacterium tuberculosis. Inhibition of mycolic acid synthesis leads to the disruption of cell wall structure and integrity, and ultimately, bacterial cell death.

Safety Information

• pictograms: GHS08
• signalword: Warning
• hcodes: H361d
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable