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SCP0068

Sigma-Aldrich

Caspase 1 Substrate

≥92% (HPLC), lyophilized

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About This Item

Empirical Formula (Hill Notation):
C31H35N7O11
Molecular Weight:
681.65
UNSPSC Code:
12352202
NACRES:
NA.32
Pricing and availability is not currently available.

Product Name

Caspase 1 Substrate, ≥92% (HPLC)

assay

≥92% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

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Show Differences

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This Item
SML1699SML0965SML2951
(S)-ZINC-3573 ≥98% (HPLC)

SML1700

(S)-ZINC-3573

(R)-ZINC-3573 ≥98% (HPLC)

SML1699

(R)-ZINC-3573

LDN-212854 ≥98% (HPLC)

SML0965

LDN-212854

SGC-CK2-1 ≥98% (HPLC)

SML2951

SGC-CK2-1

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 1 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Amino Acid Sequence

Ac-Trp-Glu-Ala-Asp-pNA

Application

Caspase 1 is a cysteine protease activator of inflammatory processes which may be detected using a variety of chromogenic and fluorogenic peptide substrates built around the VAD (val-ala-asp) or WEAD (trp-glu-ala-asp) sequences. These substrates include: Ac-VAD-pNa (acetyl-Val-Ala-Asp-p-nitroanalide), chromogenic; Ac-VAD-AFC (acetyl-Val-Ala-Asp-AFC), fluorogenic; Ac-VAD-4-methoxy-2-naphtylamide (acetyl-Val-Ala-Asp-4-methoxy-2-naphtylamide); Ac-WVAD-pNa (acetyl-Trp-Val-Ala-Asp-p-nitroanalide), chromogenic; Ac-WVAD-AMC (acetyl-Trp-Val-Ala-Asp-7-amino-4-methylcoumarin), fluorogenic; Ac-WEAD-pNA (acetyl-Trp-Glu-Ala-Asp-p-nitroanalide), chromogenic; Ac-WEAD-AMC (acetyl-Trp-Glu-Ala-Asp-7-amino-4-methylcoumarin), fluorogenic; and MCA-YVADAP-DNP-K (MCA-Tyr-Val-Ala-Asp-Ala-Pro-DNP-Lys).

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    Certificates of Analysis (COA)

    Lot/Batch Number
    LI0263

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    Eve-Lyne Marchand et al.
    Circulation research, 92(7), 777-784 (2003-03-08)
    Blockade of angiotensin type 1 (AT1) receptors induces smooth muscle cell (SMC) death and regression of aortic hypertrophy in spontaneously hypertensive rats (SHR). We postulated that SMC death and vascular remodeling in this model may be attenuated by z-Val-Ala-Asp(OMe)-CH2F (z-VAD-fmk)
    F Martinon et al.
    Cell death and differentiation, 14(1), 10-22 (2006-09-16)
    Fifteen years have passed since the cloning and characterization of the interleukin-1beta-converting enzyme (ICE/caspase-1), the first identified member of a family of proteases currently known as caspases. Caspase-1 is the prototypical member of a subclass of caspases involved in cytokine
    Annamaria Vezzani et al.
    Current opinion in investigational drugs (London, England : 2000), 11(1), 43-50 (2010-01-05)
    Epilepsy is a disabling neurological disorder that is characterized by recurring, unprovoked seizures. Drug-resistant epilepsy affects approximately 30% of individuals with epilepsy; thus, one of the main challenges for epilepsy therapy is the development of alternative anticonvulsant approaches. The discovery
    Jerry Shen et al.
    Atherosclerosis, 210(2), 422-429 (2010-01-12)
    The preferred amino acids in the proteolytic sites have been considered to be similar between caspase-1 and caspase-9, which do not support their differential functions in inflammatory pyroptosis and apoptosis. We attempted to solve this problem. We analyzed the flanking

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