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SML1455

Sigma-Aldrich

DAA-I acetate salt

≥98% (HPLC)

Synonym(s):

5-L-Isoleucine-2-10-Angiotensin I acetate salt, Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu acetate, RVYIHPFHL acetate, [Des-Asp1-Ile5]angiotensin I, des-Asp-angiotensin I acetate, des-aspartate-angiotensin-I acetate

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About This Item

Empirical Formula (Hill Notation):
C58H84N16O11 · xC2H4O2
CAS Number:
56317-01-2
Molecular Weight:
1181.39 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥98% (HPLC)

form

film

color

colorless

shipped in

wet ice

storage temp.

−20°C

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species reactivity

porcine, human, mouse, rat

species reactivity

mouse, rat, human

species reactivity

human, mouse, rat

species reactivity

rat, mouse

assay range

inter-assay cv: <10%
intra-assay cv: <5%
sensitivity: .003  ng/mL
standard curve range: 0.02 -2 ng/mL
accuracy: 101%

assay range

inter-assay cv: <15%
intra-assay cv: <10%
sensitivity: 0.14 pM
standard curve range: 0.14 -100 pM
accuracy: 96%

assay range

-

assay range

inter-assay cv: 1-10%
intra-assay cv: 0.3-7%
(Serum), inter-assay cv: 1-5%
intra-assay cv: 1-6%
(Plasma)

input

sample type plasma (K2 EDTA)
sample type serum

input

sample type plasma (K2 EDTA)
sample type serum

input

sample type cell culture supernatant
sample type plasma (K2 EDTA)
sample type serum

input

sample type serum
sample type plasma (K2 EDTA)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

technique(s)

ELISA: suitable

technique(s)

ELISA: suitable

technique(s)

ELISA: suitable

technique(s)

ELISA: suitable

detection method

chemiluminescent (425nm)

detection method

chemiluminescent (425nm)

detection method

colorimetric (450nm/590nm)

detection method

colorimetric (450nm/590nm)

Biochem/physiol Actions

DAA-I (des-aspartate-angiotensin-I) is an agonist on the angiotensin AT1 receptor and releases prostaglandins which mediate its actions. DAA-I administer at doses lesser than Km of metabolizing enzymes antagonize the deleterious actions of angiotensin II. DAA-I appear function in vivo as a physiological antagonist to angiotensin II.
DAA-I (des-aspartate-angiotensin-I) is an agonist on the angiotensin AT1 receptor.
Des-aspartate-angiotensin I (DAA-I) is a nine-amino acid angiotensin peptide[1] and a metabolite of angiotensin[2] DAA-I mediates attenuation of early inflammatory processes[1] and intercellular adhesion molecule-1 (ICAM-1) formation in animal models.[3]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    096M4703V
    105M4709V

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