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SML2264

Sigma-Aldrich

Col003

≥98% (HPLC)

Synonym(s):

2-Hydroxy-3-nitro-5-(phenylmethyl)benzaldehyde

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About This Item

Empirical Formula (Hill Notation):
C14H11NO4
CAS Number:
328565-16-8
Molecular Weight:
257.24
MDL number:
MFCD00852947
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=C(C=C(C=C1C=O)CC2=CC=CC=C2)[N+]([O-])=O

InChI

1S/C14H11NO4/c16-9-12-7-11(6-10-4-2-1-3-5-10)8-13(14(12)17)15(18)19/h1-5,7-9,17H,6H2

InChI key

RKJXVCLOGNLZOI-UHFFFAOYSA-N

Biochem/physiol Actions

Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. It binds to the collagen binding site on Hsp47. Col003 inhibits a collagen secretion by destabilization the collagen triple helix. Additionally Col003 weakly inhibits interaction of collagen with prolyl 4-hydroxylase (P4H).
cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Shinya Ito et al.
The Journal of biological chemistry, 292(49), 20076-20085 (2017-10-14)
Fibrosis can disrupt tissue structure and integrity and impair organ function. Fibrosis is characterized by abnormal collagen accumulation in the extracellular matrix. Pharmacological inhibition of collagen secretion therefore represents a promising strategy for the management of fibrotic disorders, such as

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