Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

SML2383

Sigma-Aldrich

Isosilybin

≥98% (HPLC)

Synonym(s):

Isosilybin, mixture of isomers, (2R,3R)-2-[2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one, Isosilybinin

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C25H22O10
CAS Number:
72581-71-6
Molecular Weight:
482.44
MDL number:
MFCD09842608
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O1C(C(Oc3c1cc(cc3)C4Oc5c(c(cc(c5)O)O)C(=O)C4O)c2cc(c(cc2)O)OC)CO

InChI

1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3

InChI key

FDQAOULAVFHKBX-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
MABN2394HPA002191MAB336
Anti-Syntaxin-3 Antibody, clone 1-146 clone 1-146, from mouse

MAB2258

Anti-Syntaxin-3 Antibody, clone 1-146

Anti-Syntaxin-3B Antibody, clone 12E5 clone 12E5, from mouse

MABN2394

Anti-Syntaxin-3B Antibody, clone 12E5

Anti-STX3 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

HPA002191

Anti-STX3 antibody produced in rabbit

Anti-Syntaxin Antibody, clone SP8 ascites fluid, clone SP8, Chemicon®

MAB336

Anti-Syntaxin Antibody, clone SP8

Gene Information

human ... STX3(6809)
rat ... Stx3(81802)

Gene Information

mouse ... Stx3(20908)

Gene Information

human ... STX3(6809)

Gene Information

human ... STX1A(6804)

species reactivity

human, rat

species reactivity

mouse, human, bovine

species reactivity

human

species reactivity

hamster, human, pig, rat

antibody form

purified antibody

antibody form

purified antibody

antibody form

affinity isolated antibody

antibody form

ascites fluid

clone

1-146, monoclonal

clone

12E5, monoclonal

clone

polyclonal

clone

SP8, monoclonal

biological source

mouse

biological source

mouse

biological source

rabbit

biological source

mouse

isotype

IgG1κ

isotype

IgG2aκ

isotype

-

isotype

IgG1

Biochem/physiol Actions

Isosilybin is a diastereoisomeric mixture of flavonolignans isosilybin A and isosilybin B isolated from milk thistle (Silybum marianum) that exhibits hepatoprotective activity. Isosilybin potently inhibits Cytochrome P4502C8 (CYP2C8) activity in human liver microsomes. Also Isosilybin is an activator of PPARγ.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number

    It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

    If you need assistance, please contact Customer Support

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Customers Also Viewed

    Slide 1 of 1

    1 of 1

    Silymarin flavonolignans

    Sigma-Aldrich

    S0292

    Silymarin

    Daniëlle Rianne José Verboogen et al.
    eLife, 6 (2017-05-20)
    SNARE proteins play a crucial role in intracellular trafficking by catalyzing membrane fusion, but assigning SNAREs to specific intracellular transport routes is challenging with current techniques. We developed a novel Förster resonance energy transfer-fluorescence lifetime imaging microscopy (FRET-FLIM)-based technique allowing
    Adrian J Giovannone et al.
    Molecular biology of the cell, 28(21), 2843-2853 (2017-08-18)
    Syntaxin 3 (Stx3), a SNARE protein located and functioning at the apical plasma membrane of epithelial cells, is required for epithelial polarity. A fraction of Stx3 is localized to late endosomes/lysosomes, although how it traffics there and its function in
    Hiroshi Gomi et al.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 65(11), 637-653 (2017-09-16)
    The comparative structure and expression of salivary components and vesicular transport proteins in the canine major salivary glands were investigated. Histochemical analysis revealed that the morphology of the five major salivary glands-parotid, submandibular, polystomatic sublingual, monostomatic sublingual, and zygomatic glands-was
    Poppy Datta et al.
    The Journal of biological chemistry, 294(50), 19119-19136 (2019-11-07)
    Mutations in the centrosomal protein 290 (CEP290) gene cause various ciliopathies involving retinal degeneration. CEP290 proteins localize to the ciliary transition zone and are thought to act as a gatekeeper that controls ciliary protein trafficking. However, precise roles of CEP290
    Poppy Datta et al.
    PloS one, 16(5), e0246358-e0246358 (2021-05-08)
    Nephrocystin (NPHP1) is a ciliary transition zone protein and its ablation causes nephronophthisis (NPHP) with partially penetrant retinal dystrophy. However, the precise requirements of NPHP1 in photoreceptors are not well understood. Here, we characterize retinal degeneration in a mouse model
    View All Related Papers

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service