SML2798
CH625
≥98% (HPLC)
Synonym(s):
(2E)-1-(4-Hydroxy-2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, 4,4′-Dihydroxy-2′,6′-dimethoxychalcone, ZINC95910725
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About This Item
Empirical Formula (Hill Notation):
C17H16O5
CAS Number:
Molecular Weight:
300.31
UNSPSC Code:
51111800
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
CH625 is a potent and selective competitive inhibitor of CYP4X1 that decreases tumor burden, increases survival in glioma intracranial and subcutaneous model in rats. CH625 normalizes tumor vasculature in the C6 and GL261 gliomas through tumor-associated macrophages (TAMs) reprograming and inhibition of VEGF and TGF-β production.
potent and selective competitive inhibitor of CYP4X1 that decreases tumor burden, increases survival in gliomas
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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