SML3426

Glycerol phenylbutyrate

≥95% (HPLC)

• Synonym(s): 1,2,3-Propanetriyl tris(4-phenylbutanoate), GPB, Glyceryl tri-[4-phenylbutyrate, HPN 100, Tri(4-phenylbutyryl)glycerol
• Empirical Formula (Hill Notation): C₃₃H₃₈O₆
• CAS Number: 611168-24-2
• Molecular Weight: 530.65
• MDL number: MFCD28016960
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: oil
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C(OCC(OC(CCCC1=CC=CC=C1)=O)COC(CCCC2=CC=CC=C2)=O)CCCC3=CC=CC=C3
• InChI key: ZSDBFLMJVAGKOU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Glycerol phenylbutyrate, a triacylglycerol, is a prodrug of ER stress inhibitor 4-phenylbutyric acid (PBA). Glycerol phenylbutyrate is a nitrogen-binding agent approved for the chronic management of adult and pediatric patients (≥2 years of age) with urea cycle disorders (UCDs) who cannot be managed by dietary protein restriction and/or amino acid supplementation alone.

Prodrug of ER stress inhibitor 4-phenylbutyric acid (PBA); ammonia scavenger

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable