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U3750

Sigma-Aldrich

Uridine

≥99%

Synonym(s):

1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside

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About This Item

Empirical Formula (Hill Notation):
C9H12N2O6
CAS Number:
Molecular Weight:
244.20
Beilstein/REAXYS Number:
754902
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51

Pricing and availability is not currently available.

biological source

synthetic (organic)

Quality Level

assay

≥99%

form

powder

mp

163-167 °C (lit.)

solubility

H2O: 50 mg/mL, clear, colorless

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1

InChI key

DRTQHJPVMGBUCF-XVFCMESISA-N

Gene Information

mouse ... Uck1(22245)

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Show Differences

1 of 4

This Item
14572693851T3754
L-Tyrosine reagent grade, ≥98% (HPLC)

T3754

L-Tyrosine

form

crystalline

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

99%

assay

≥96.0% (NT)

assay

≥98% (HPLC)

mp

280-285 °C (dec.) (lit.)

mp

≥300 °C (lit.)

mp

~260 °C (dec.)

mp

>300 °C (dec.) (lit.)

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

200

solubility

1 M HCl: soluble

solubility

-

solubility

-

solubility

1 M HCl: soluble 50 mg/mL

color

off-white to yellow

color

-

color

white to faint brown

color

white to off-white

General description

Uridine is a uracil nucleoside, specific for RNA sequence. Uridine is present in blood, seminal fluid and cerebrospinal fluid.[1] Uridine is synthesized in living organisms by de novo and salvage pathways.

Application

Uridine has been used:
  • as a component of hippocampal neuron medium for culture of primary hippocampal neuron cells[2]
  • in uridine rescue experiments in mouse embryonic fibroblasts and human breast cancer cells[3]
  • in chase sequencing experiments[4]

Biochem/physiol Actions

Uridine monophosphate is essential for protein glycosylation, polysaccharide biosynthesis and lipid metabolism. Oral administration of uridine is suggested for anisopoikilocytosis and epileptic encephalopathy disorders.[5] Uridine has numerous biological functions like treating dry eye syndrome, regulating nervous system and favors reproduction. High levels of uridine are implicated in insulin resistance.[1]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Sylvia Lee-Huang et al.
Biochemical and biophysical research communications, 354(4), 872-878 (2007-02-06)
We have identified oleuropein (Ole) and hydroxytyrosol (HT) as a unique class of HIV-1 inhibitors from olive leaf extracts effective against viral fusion and integration. We used molecular docking simulation to study the interactions of Ole and HT with viral
Oleuropein, a phenolic compound in extra virgin olive oil, increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats
Oi-Kano Y
J. Nutr. Sci. Vitaminol., 54, 363-370 (2008)
Carla Marchetti et al.
Evidence-based complementary and alternative medicine : eCAM, 2015, 908493-908493 (2015-12-23)
Malignant mesothelioma is a poor prognosis cancer in urgent need of alternative therapies. Oleuropein, the major phenolic of olive tree (Olea europaea L.), is believed to have therapeutic potentials for various diseases, including tumors. We obtained an oleuropein-enriched fraction, consisting
Oleuropein in olive and its pharmacological effects
Omar SH
Scientia Pharmaceutica, 78(2), 133-154 (2010)
Ioanna Andreadou et al.
The Journal of nutrition, 136(8), 2213-2219 (2006-07-22)
Thgoal of this study was to evaluate the efficacy of the antioxidant olive constituent, oleuropein, on infarct size, oxidative damage, and the metabolic profile in rabbits subjected to ischemia. Oleuropein, 10 or 20 mg/(kg x d), was administered to 8

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