U3750

Uridine

≥99%

• Synonym(s): 1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside
• Empirical Formula (Hill Notation): C₉H₁₂N₂O₆
• CAS Number: 58-96-8
• Molecular Weight: 244.20
• Beilstein/REAXYS Number: 754902
• EC Number: 200-407-5
• MDL number: MFCD00006526
• UNSPSC Code: 41106305
• PubChem Substance ID: 24900640
• NACRES: NA.51

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• assay: ≥99%
• form: powder
• mp: 163-167 °C (lit.)
• solubility: H₂O: 50 mg/mL, clear, colorless
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
• InChI: 1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
• InChI key: DRTQHJPVMGBUCF-XVFCMESISA-N
• Gene Information: mouse ... Uck1(22245)

Description

General description

Uridine is a uracil nucleoside, specific for RNA sequence. Uridine is present in blood, seminal fluid and cerebrospinal fluid.[1] Uridine is synthesized in living organisms by de novo and salvage pathways.

Application

Uridine has been used:

• as a component of hippocampal neuron medium for culture of primary hippocampal neuron cells[2]
• in uridine rescue experiments in mouse embryonic fibroblasts and human breast cancer cells[3]
• in chase sequencing experiments[4]

Biochem/physiol Actions

Uridine monophosphate is essential for protein glycosylation, polysaccharide biosynthesis and lipid metabolism. Oral administration of uridine is suggested for anisopoikilocytosis and epileptic encephalopathy disorders.[5] Uridine has numerous biological functions like treating dry eye syndrome, regulating nervous system and favors reproduction. High levels of uridine are implicated in insulin resistance.[1]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)