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U9382

Sigma-Aldrich

Ubiquitin-Carrier Protein H10 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli (histidine-tagged), buffered aqueous glycerol solution

Synonym(s):

UbcH10

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About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.32

Pricing and availability is not currently available.

biological source

human

Quality Level

recombinant

expressed in E. coli (histidine-tagged)

assay

≥95% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~20 kDa

technique(s)

ligand binding assay: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

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This Item
U9132U5382P3988
recombinant

expressed in E. coli (histidine-tagged)

recombinant

expressed in E. coli

recombinant

expressed in E. coli (N-terminal FLAG® tagged)

recombinant

-

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

technique(s)

ligand binding assay: suitable

technique(s)

-

technique(s)

mass spectrometry (MS): suitable

technique(s)

-

biological source

human

biological source

-

biological source

human

biological source

rabbit

form

buffered aqueous glycerol solution

form

liquid

form

lyophilized powder

form

solution

mol wt

~20 kDa

mol wt

18 kDa

mol wt

10 kDa

mol wt

700 kDa

General description

Manufactured for Sigma by Boston Biochem., Inc.

Application

Ubiquitin-Carrier Protein H10 (UbcH10) human may be used to study the role of ubiquitin-proteasome system in pathogenesis of human diseases.

Biochem/physiol Actions

In conjunction with anaphase-promoting complex, catalyzes both cyclin A and cyclin B destruction.
In conjunction with the anaphase-promoting complex, the protein catalyzes the destruction of both cyclin A and cyclin B.
Ubiquitin-Carrier Protein H10 human also referred to as UbcH10 is a recombinant protein that catalyzes the destruction of cyclin A as well as cyclin B along with the anaphase promoting complex and hence plays a pivotal role in controlling the cell exit from mitosis.[1]

Physical form

Solution in 50 mM HEPES, pH 8.0, 125 mM NaCl, and 1 mM DTT in 10% glycerol.

wgk_germany

WGK 1


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    Li Zhu et al.
    The Journal of biological chemistry, 288(44), 32050-32063 (2013-09-21)
    Recent studies link synaptojanin 1 (synj1), the main phosphoinositol (4,5)-biphosphate phosphatase (PI(4,5)P2-degrading enzyme) in the brain and synapses, to Alzheimer disease. Here we report a novel mechanism by which synj1 reversely regulates cellular clearance of amyloid-β (Aβ). Genetic down-regulation of
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