790443

TCO-PEG3-maleimide

• Synonyme(s) : trans-Cyclooctene-maleimide
• Formule empirique (notation de Hill) : C₂₆H₄₁N₃O₈
• Poids moléculaire : 523.62
• Numéro MDL: MFCD28053553
• Code UNSPSC : 12352111
• ID de substance PubChem : 329768215
• Nomenclature NACRES : NA.22

Propriétés

• Forme: liquid
• Niveau de qualité: 100
• Capacité de réaction: reaction type: click chemistry
• Pertinence de la réaction: reagent type: linker
• Groupe fonctionnel: maleimide
• Température de stockage: −20°C
• Chaîne SMILES: O=C(NCCCOCCOCCOCCCNC(CCN1C(C=CC1=O)=O)=O)OC2CCC/C=C/CC2
• InChI: 1S/C26H41N3O8/c30-23(12-15-29-24(31)10-11-25(29)32)27-13-6-16-34-18-20-36-21-19-35-17-7-14-28-26(33)37-22-8-4-2-1-3-5-9-22/h1-2,10-11,22H,3-9,12-21H2,(H,27,30)(H,28,33)/b2-1+
• Clé InChI: BJZRPWAVCDJCTC-OWOJBTEDSA-N

Description

Actions biochimiques/physiologiques

Maleimide (thiol reactive) functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into thiol containing compounds or biomolecules. Trans-cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1; 2; 4; 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging. The PEG spacer allows for increased water solubility; less aggregation and an increased distance between the thiol to be modified and the reactive alkene.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable