487928

Nocodazole

≥99% (HPLC), solid, microtuble inhibitor, Calbiochem

• Synonyme(s) : Nocodazole, R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
• Formule empirique (notation de Hill) : C₁₄H₁₁N₃O₃S
• CAS Number: 31430-18-9
• Poids moléculaire : 301.32
• Numéro MDL: MFCD00005588
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Nocodazole, Inhibitor of mitosis.
• Niveau de qualité: 100
• Description: RTECS - DD6521000
• Essai: ≥99% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: pale yellow
• Solubilité: DMSO: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 10-30°C
• Chaîne SMILES: [s]1c(ccc1)C(=O)c2cc3nc([nH]c3cc2)NC(=O)OC
• InChI: 1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
• Clé InChI: KYRVNWMVYQXFEU-UHFFFAOYSA-N

Description

Description générale

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Promotes tubulin depolymerization

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.

Autres remarques

Park, H., et al. 2011. Chem. Med. Chem.in press.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.
Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H341,H361d
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Muta. 2 - Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable