428020

Latrunculin B

from Latrunculia magnifica, ≥95% (HPLC), solid, actin polymerization inhibitor, Calbiochem^®

• Synonyme(s) : Latrunculin B, Latrunculia magnifica
• Formule empirique (notation de Hill) : C₂₀H₂₉NO₅S
• CAS Number: 76343-94-7
• Poids moléculaire : 395.51
• Numéro MDL: MFCD00270879
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Latrunculin B, Latrunculia magnifica, Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.
• Niveau de qualité: 100
• Description: Merck USA index - 14, 5378
• Essai: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: off-white to yellow
• Solubilité: DMSO: 25 mg/mL; ethanol: 25 mg/mL; methanol: 50 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: S1C[C@H](NC1=O)[C@@]2(O[C@H]3C[C@@H](OC(=O)\C=C(/CC\C=C/[C@H](CC3)C)\C)C2)O
• InChI: 1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
• Clé InChI: NSHPHXHGRHSMIK-JRIKCGFMSA-N

Description

Description générale

A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes. 10 to 100-fold more potent than cytochalasins.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Actin polymerization

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Harmful (C)

Autres remarques

Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.
de Oliveira, C.A., and Mantovani, B. 1988. Life Sci.43, 1825.
Coue, M., et al. 1987. FEBS Lett.213, 316.
Spector, I., et al. 1983. Science219, 493.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable