I0500000

Isoniazid

European Pharmacopoeia (EP) Reference Standard

• Synonyme(s) : 4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide
• Formule empirique (notation de Hill) : C₆H₇N₃O
• CAS Number: 54-85-3
• Poids moléculaire : 137.14
• Beilstein: 119374
• Numéro MDL: MFCD00006426
• Code UNSPSC : 41116107
• ID de substance PubChem : 329815311
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: pharmaceutical primary standard
• Agence: EP Reference Standard
• Famille d'API: isoniazid
• Fabricant/nom de marque: EDQM
• Pf: 171-173 °C (lit.)
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Température de stockage: 2-8°C
• Chaîne SMILES: NNC(=O)c1ccncc1
• InChI: 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
• Clé InChI: QRXWMOHMRWLFEY-UHFFFAOYSA-N

Description

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Isoniazid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315
• Conseils de prudence: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Classification des risques: Acute Tox. 4 Oral - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3